Cambridge Healthtech Institute’s Inaugural

Lead and Candidate Selection for Therapeutic Proteins  

September 16-17, 2020


The screenings and studies that comprise a company's lead and candidate selection funnel are an essential stage of biopharmaceutical R&D, and good selections not only ensure that the best quality molecules are chosen for advancement, but that these match target profiles for efficacy, safety and pharmacology. The Lead and Candidate Selection for Therapeutic Proteins meeting presents a wide range of strategies, models and technologies used for these evaluations, and considers the best practices in this field. Case studies from both large and small organizations will showcase the innovative ways organizations have employed these tools to help ensure rapid progression through subsequent development steps and the prospects for success in the clinic.


Coverage will include, but is not limited to:        

Emerging Technologies

  • The interface between modeling and engineering; experimental validation of structural modeling and rational design
  • Application of machine learning in lead selection
  • Advanced assays for microfluidic and single cell screening
  • Practical limitations of candidate screening; number of candidates, throughput, cost

Lead Selection Screening Funnel Strategies

  • Strategies for small and large biotechs
  • Optimizing speed and quality of predictions
  • Selection and timing of assays and studies: biophysical characterization, drug-like properties, off-target binding, developability analysis, immunogenicity, polyreactivity
  • Application of new informatics and analytical technologies

Functional Assays

  • Phenotypic antibody discovery; function-first screening
  • Developing and/or sourcing of highly specialized assays
  • Functional assays for complex molecules
  • The impact of affinities and epitopes on function


  • Early stage safety screening; immunogenicity prediction and mitigation
  • Early stage potency assays
  • De-risking of novel proteins
  • Understanding screening bias; are good candidates being deselected too soon?


If you would like to submit a proposal to give a presentation at this meeting, please click here.


The deadline for priority consideration is February 26, 2020.


All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


For more details on the conference, please contact:
Kent Simmons

Senior Conference Director

Cambridge Healthtech Institute

Phone: (+1) 207-869-9199


For partnering and sponsorship information, please contact:
Rod Eymael

Manager, Business Development

Cambridge Healthtech Institute

Phone: (+1) 781-247-6286