Cambridge Healthtech Institute’s 15th Annual

GPCR-Based Drug Discovery

Targeting G Protein-Coupled Receptors for New Therapeutic Options

September 17-18, 2020


G protein-coupled receptors (GPCRs) have been a medically relevant drug target for decades because of the central roles they play in a variety of physiological processes. At least 25% of the drugs on the market achieve their effect via GPCRs. The receptors are a challenging target class to work with, however, because they are embedded in the membrane and have complex signaling properties (a single type of GPCR can couple to and activate or inhibit a variety of G proteins). Recent advances in biophysical screening approaches though are facilitating GPCR-targeted drug discovery. Cryo-electron microscopy and X-ray crystallography improvements have also aided drug discovery against GPCRs. Join us at the 15th Annual GPCR-Based Drug Discovery conference, part of Discovery on Target, to hear about examples of early drug discovery work with newer approaches and GPCR-targeted candidates progressing in the pipeline.


Who should attend: Industry and Academic Discovery Biologists, Structural Biologists, Pharmacologists, Discovery Chemists, Medicinal Chemists, Biophysical Chemists, Computational Chemists, Receptor Pharmacologists, Neuro-Pharmacologists, CNS Translational Researchers.


Coverage will include, but is not limited to:                                        

  • GPCR structural insights from new cryoEM and X-ray crystal structures
  • Discovery and development of GPCR-biased agonist and allosteric modulators
  • Biosensor-based screens of GPCRs in their native state
  • GPCR-targeted clinical candidates
  • Receptor ubiquitination, trafficking, desensitization, and impact on drug discovery
  • Receptor-ligand binding kinetics and drug discovery implications
  • Biophysical techniques, such as SPR and NMR, applied to GPCRs


If you would like to submit a proposal to give a presentation at this meeting, please click here.


The deadline for priority consideration is February 26, 2020.


All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


For more details on the conference, please contact:

Anjani Shah, PhD

Senior Conference Director

Cambridge Healthtech Institute

Phone: (+1) 781-247-6252



For partnering and sponsorship information, please contact:

Rod Eymael

Manager, Business Development

Cambridge Healthtech Institute

Phone: (+1) 781-247-6286