Cambridge Healthtech Institute’s 7th Annual

Lead Generation Strategies

Small Molecule Drug Discovery Innovations

September 27-28, 2023


Cambridge Healthtech Institute’s annual Lead Generation Strategies conference tracks the latest approaches used by medicinal, biophysical and computational chemists to discover and develop small molecules (and now slightly larger molecules that retain potential for oral bioavailability) into drug candidates. Join us to hear case studies applying orthogonal biophysical approaches and other methods such as DNA-encoded libraries (DEL) and fragment-based drug design (FBDD) to hit-finding against what were once considered undruggable targets. These newer tools have enabled screening against non-traditional intracellular drug targets such as protein or nucleic acid/protein complexes involving protein-protein interactions (PPIs) and enzymes with hard-to-reach catalytic sites.


Who should attend: Scientists, Resesearchers and Directors from Academics and Industry working in: Medicinal Chemistry, Discovery Chemistry, Biophysics, Structure-based Drug Design, Organic Chemistry, Computational Chemistry.


Coverage will include, but is not limited to:


  • Hit-to-Lead and drug lead optimization case studies for difficult targets (PPIs, membrane proteins and more)
  • New biophysical methods such as affinity selection mass spectrometry (ASMS)
  • Innovations in structure-based drug design (cryoEM and computational approaches) 
  • Virtual screening and AI applications for hit to lead discovery programs
  • Hit-finding strategies: encoded libraries, fragment screens, ultra high throughput virtual ligand screens
  • Covalent fragments as starting points for small molecule inhibitor discovery
  • Solutions for and examples of ‘successful’ bRo5 molecules such as oral and macrocyclic peptides


The deadline for priority consideration is March 17, 2023.


All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


Opportunities for Participation:



For more details on the conference, please contact:

Anjani Shah, PhD

Senior Conference Director

Cambridge Healthtech Institute

Phone: (+1) 781-247-6252



For sponsorship information, please contact:

Kristin Skahan

Senior Business Development Manager

Cambridge Healthtech Institute

Phone: (+1) 781-972-5431