Cambridge Healthtech Institute’s Inaugural
Small G Proteins
Targeting Ras, Other Monomeric GTPases and Their Molecular Partners
September 16-17, 2020
Small G proteins are a super family of intracellular enzymes with similar core structures that hydrolyze GTP molecules and play roles important to cell growth and other core cellular processes. The most ‘famous’ small G protein sub family,
Ras proteins, has been known for decades to contribute to the growth of many types of cancerous cells when Ras is stuck in its ‘ON’, GTP-bound state. Yet drug discovery efforts to find small molecule drugs to turn Ras ‘off’
have been difficult because it’s part of difficult-to-drug molecular complexes. Thanks to new biophysical approaches, there are a few anti-Ras compounds in early-stage clinical trials and the field of targeting small G protein regulatory complexes
has been rejuvenated. Join CHI’s Inaugural Small G Proteins conference to hear from drug discovery chemists, biologists and pharmacologists working on ‘Ras’ and other small G protein-related projects.
Who should attend: Discovery Biologists, Discovery Chemists, Immuno-Oncologists, Cancer Researchers from Pharma and Biotech Companies and Academic Institutions.
Coverage will include, but is not limited to:
- Biophysical approaches that led to anti-Ras clinical stage compounds
- Review of KRAS targeted compounds in the clinic
- Progress in targeting non-Ras small G proteins: Rho (cell shape), Rab (intracellular trafficking), Raf (vesicular transport), Ran (nuclear transport)
- Targeting ‘partners’ of small G protein associated proteins (GTPase activating proteins [GAPs], Guananine Exchange Factors [GEFs])
- Allosteric inhibitors of small G proteins (e.g., SHP2)
If you would like to submit a proposal to give a presentation at this meeting, please click here.
The deadline for priority consideration is February 26, 2020.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
For more details on the conference, please contact:
Anjani Shah, PhD
Senior Conference Director
Cambridge Healthtech Institute
Phone: (+1) 781-247-6252
Email: ashah@healthtech.com
For partnering and sponsorship information, please contact:
Rod Eymael
Manager, Business Development
Cambridge Healthtech Institute
Phone: (+1) 781-247-6286
Email: reymael@healthtech.com