Cambridge Healthtech Institute’s Inaugural

Small G Proteins

Targeting Ras, Other Monomeric GTPases and Their Molecular Partners

September 16-17, 2020


Small G proteins are a super family of intracellular enzymes with similar core structures that hydrolyze GTP molecules and play roles important to cell growth and other core cellular processes. The most ‘famous’ small G protein sub family, Ras proteins, has been known for decades to contribute to the growth of many types of cancerous cells when Ras is stuck in its ‘ON’, GTP-bound state. Yet drug discovery efforts to find small molecule drugs to turn Ras ‘off’ have been difficult because it’s part of difficult-to-drug molecular complexes. Thanks to new biophysical approaches, there are a few anti-Ras compounds in early-stage clinical trials and the field of targeting small G protein regulatory complexes has been rejuvenated. Join CHI’s Inaugural Small G Proteins conference to hear from drug discovery chemists, biologists and pharmacologists working on ‘Ras’ and other small G protein-related projects.


Who should attend: Discovery Biologists, Discovery Chemists, Immuno-Oncologists, Cancer Researchers from Pharma and Biotech Companies and Academic Institutions.


Coverage will include, but is not limited to:

  • Biophysical approaches that led to anti-Ras clinical stage compounds
  • Review of KRAS targeted compounds in the clinic
  • Progress in targeting non-Ras small G proteins: Rho (cell shape), Rab (intracellular trafficking), Raf (vesicular transport), Ran (nuclear transport)
  • Targeting ‘partners’ of small G protein associated proteins (GTPase activating proteins [GAPs], Guananine Exchange Factors [GEFs])
  • Allosteric inhibitors of small G proteins (e.g., SHP2)


If you would like to submit a proposal to give a presentation at this meeting, please click here.


The deadline for priority consideration is February 26, 2020.


All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


For more details on the conference, please contact:
Anjani Shah, PhD

Senior Conference Director

Cambridge Healthtech Institute

Phone: (+1) 781-247-6252


For partnering and sponsorship information, please contact:
Rod Eymael

Manager, Business Development

Cambridge Healthtech Institute

Phone: (+1) 781-247-6286