Cambridge Healthtech Institute’s 2nd Annual

Small G Proteins

Targeting KRAS and Other GTPases

September 29-30, 2021


KRAS and other members of the Ras family of small G proteins have been known for years to be highly associated, in their mutated forms, with a variety of cancers, thereby establishing Ras proteins as controllers of cellular growth. But only recently have RAS-targeted drug candidates, specifically against KRAS, entered clinical trials thanks to innovative medicinal chemistry and biophysical approaches. Small G proteins lack structural features in their enzymatic GPTase domain typically required for binding of small molecule inhibitors. With KRAS progress cracking-open the field, drug discovery attention has also turned to other types of Ras proteins and even other small G proteins such as Rho and Rab that play structural or other signaling roles in the cell. Join your drug discovery colleagues at Cambridge Healthtech Institute’s Small G Proteins conference to keep abreast of KRAS progress and compare and contrast approaches for targeting related family members.


Who should attend: Discovery Oncologists, Discovery Biologists, Discovery Chemists, Immuno-Oncologists, Cancer Researchers from Pharma, Biotech and Academic institutions


Coverage will include, but is not limited to:


  • KRAS-targeted compounds progressing in drug development
  • Targeting other KRAS mutants (non G12C forms)
  • Targeting Ras-interacting partners: SOS proteins, GTPase Activating Proteins (GAPS), Guanine Exchange Factors (GEFs) 
  • Allosteric inhibitors of small G proteins (SHP2)
  • Structural insights into GTPases
  • Updates on targeting non-Ras Small G Proteins (Rho, Rab, Raf, Ral, Ran) 


If you would like to submit a proposal to give a presentation at this meeting, please click here.


The deadline for priority consideration is March 29, 2021.


All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


For more details on the conference, please contact:

Anjani Shah, PhD

Senior Conference Direcctor

Cambridge Healthtech Institute

Phone: (+1) 781-247-6252



For partnering and sponsorship information, please contact:

Rod Eymael

Manager, Business Development

Cambridge Healthtech Institute

Phone: (+1) 781-247-6286


Submit a Speaker Proposal