One Kendall Sq. Bldg. 200 Ste. B2304
As an innovator in reagents and tools, Abcam’s purpose is to serve life science researchers globally to achieve their mission, faster. Providing the research and clinical communities with tools and scientific support, Abcam offers highly
validated biological binders and assays to address important targets in critical biological pathways.
AbCellera partners to discover and develop next-generation therapeutic antibodies. Our team integrates end-to-end capabilities in proprietary immunizations, microfluidics, genomics, and computation to develop innovative strategies that overcome
tough challenges and advance discovery programs. We quickly deliver large and diverse panels of high-quality antibodies from any species, including humans.
AbCheck discovers and optimizes human antibodies for therapeutic applications leveraging several proprietary platforms including in vitro and in vivo technologies.
AbCheck delivers high quality leads with subnanomolar affinities and good stabilities which are compatible with different antibody designs including bispecifics.
ABIVAX is mobilizing the body’s natural immune machinery to treat patients with viral infections, autoimmune diseases and cancer. A clinical-stage company, ABIVAX leverages its antiviral and immune enhancing platforms to optimize candidates
to treat ulcerative colitis and other inflammatory diseases, viral diseases and liver cancer.
10581 Roselle Street Suite 115
Ablexis and AlivaMab Discovery Services together deliver unparalleled capabilities in the discovery of human therapeutic antibodies. AlivaMab Discovery Services provides companies comprehensive, customized therapeutic antibody discovery
solutions using the AlivaMabTM Mouse, a best-in-class discovery platform already in use at the majority of the top-15 pharmas and now more broadly available.
Agilent Technologies Inc. is a global leader in life sciences, diagnostics and applied chemical markets. With more than 50 years of insight and innovation, Agilent instruments, software, services, solutions, and people provide trusted answers
to its customers' most challenging questions. Agilent employs about 13,500 people worldwide.
Aldevron serves the biotechnology industry with custom production of nucleic acids, proteins, and antibodies. Featuring the largest and most modern GMP plasmid DNA facility in the world, thousands of clients use Aldevron-produced plasmids,
RNA and gene editing enzymes for projects ranging from research grade to clinical trials to commercial applications.
AMRI, a global contract research and manufacturing organization, partners with the pharmaceutical and biotechnology industries to improve patient outcomes and quality of life. With locations across the globe, AMRI’s team combines
scientific expertise and market-leading technology to provide a complete suite of solutions from Discovery to finished Drug Product.
AMSBIO, a global provider of advanced life science technology. Experts in making oncology assays more physiologically relevant, our products and services include antibodies, peptides and recombinant proteins, tools for spheroid and organoid
culture as well as systems for studying cell motility, migration, invasion and proliferation. Cancer screening service now available.
101 N. Chestnut St Suite 104
ASINEX focuses on cutting edge compound libraries that incorporate expertise in both medicinal chemistry and biology resulting in novel small molecules with improved cell permeability and bioavailability. The most recent developments include
cell permeable macrocycles for challenging intramolecular targets and novel chemical entities for targeting RNA.
BioCity Nottingham Pennyfoot Street
Aurelia Bioscience is a UK based contract research organisation specialising in bioassay development, pharmacological profiling and compound screening. Scientists at Aurelia Bioscience have decades of experience in pre-clinical discovery,
designing and developing low, medium and high throughput assays for pharmacological profiling, hits-to-lead, lead identification and lead optimisation.
BellBrook Labs is dedicated to accelerating drug discovery and biological research by providing innovative high throughput screening solutions for enzymatic targets. Transcreener® HTS Assays make it easy to screen thousands of different
targets including kinases, ATPases, GTPases, methyltransferases, glycosyltransferases and more!
555 Montgomery Street, Suite 1100
Benchling is the leader in cloud-based informatics for life science R&D. The company offers a platform purpose-built for large molecule R&D, incorporating six natively unified applications: Notebook, Molecular Biology, Inventory, Registry,
Workflows, and Requests. Over 170,000 scientists use Benchling globally across pharmaceutical corporations, leading biotech companies, and research institutions.
Newhouse, Lanarkshire, ML1 5UH
BioAscent is a leading provider of integrated drug discovery services based at the former Merck R&D site in Newhouse, Scotland, UK.
Our services include assay development and screening, medicinal chemistry, computational chemistry and compound management, all with access to our library of 125,000 lead-like compounds.
3802 Spectrum Blvd, Ste 154
BioMedTech’s coated surfaces enable spheroid-formation, cell-attachment or immuno-assays. Surfaces include bioSphere™ 3D-Spheroid-Forming, Fibronectin, BME/Matrigel, Laminin(s), Collagen(s), PDL, PLL, PLO, PEI, Protein A/G, Streptavidin,
Avidin, Antibodies and our EvaluPlate tool. All 1536-,384-, 96-well & multiwell formats are supported, including glass-bottom and new Ultra-Low-Base platforms, supporting high-resolution confocal imaging systems
639 Queen Street West, Unit 401
Toronto, ON M5V 2B7
BioRender is an easy-to-use graphics tool for creating high-quality science figures for presentations, publications, internal communication and more! It’s 50x faster and more effective than PowerPoint, Adobe Illustrator, or hiring external vendors. BioRender combines powerful drawing tools with a library of 30,000+ scientifically accurate icons and templates. Sign up free at www.biorender.com
Biosensing Instrument’s new SPRm 200 is the world’s first commercial SPR Microscopy, which integrates optical imaging and SPR technology. Designed especially for in-vitro, label-free measurement of binding
activity and cell kinetics, SPRm 200 provides a spatial visualization of cellular structures together with local binding of cell membrane proteins.
Carterra® is a leading provider of innovative technologies designed to accelerate the discovery of novel therapeutic candidates. Carterra’s high throughput LSA™ instrument for monoclonal antibody screening and characterization
combines patented microfluidics technology with real-time High Throughput Surface Plasmon Resonance (HT-SPR) and industry leading Kinetic and Epitope analysis and visualization software.
Cellecta is a leading provider of genomic products and services. Our functional genomics portfolio includes gene knockout and knockdown screening services; custom and genome-wide CRISPR, RNAi and barcode libraries; construct services, cell
engineering, NGS and targeted RNA-Seq products and services. We can help your discovery efforts.
Discovery from Charles River is the CRO of choice with a proven track record of successful drug development. Offering scientific excellence and integrated services that take clients from hit ID to IND, our client-focused collaborative team
works with clients to find and follow the optimum path to market.
11199 Sorrento Valley Road, Suite 206
ChemBridge is a global provider of chemistry products and services for small molecule drug discovery, chemical biology, and agrochemical discovery programs. Our portfolio includes over 1.3 million diverse and target-focused screening compounds,
11,000 synthetic macrocycles, over 14,000 chemical building blocks, and high-end, research-intensive custom library and medicinal chemistry support services.
1010 Sherbrooke Street West, Suite 910
CCG (Chemical Computing Group) is a leading supplier of software solutions for life sciences. With a proven track record in scientific innovation, CCG provides state-of-the-art applications in drug discovery to pharmaceutical, biotechnology
and academic researchers. CCG headquarters are in Montreal (Canada), with support offices in North America, Europe and Asia.
280 Utah Avenue, Suite 100
South San Francisco, CA 94080
ChemPartner is a global full-service life science CRO/CDMO with over 15 years of pharmaceutical research experience. With a team of over 2000 experienced scientists, hundreds of western-trained industry leaders, and experienced executive leadership
at the helm, ChemPartner is aligned and dedicated to technically and strategically accomplishing your global research initiatives.
2214 Blvd de la Lironde Parc Agropolis 2 - Bâtiment 12
Montferrier sur Lez, France 34980
CILcare is a unique CRO specialized in ear disorders. We offer preclinical services, efficacy and GLP toxicology studies, as well as consultancy, to accelerate the development of innovative products for hearing loss, tinnitus and otic disorders.
Cisbio is a life sciences company with 30+ years of experience in in vitro diagnostics and drug discovery, providing technical solutions to the global scientific community. With our proprietary technology, HTRF (homogeneous
florescence detection), we offer best-in-class assays and services for pharmaceutical, biotechnology, academia, and contract research organizations worldwide.
1633 Bayshore Hwy, Suite #342
Collaborative Drug Discovery - provides a beloved software solution for cloud-based drug discovery. CDD Vault is an affordable platform enabling users to organize chemical & biological data & collaborate within labs or across
the globe through an intuitive web interface. Activity and Registration, Data Visualization, Electronic Lab Notebook.
43401 Duncan Avenue, Suite 400
St Louuis, Missouri 63110
Confluence Discovery Technologies (CDT) provides custom outsourced solutions across the spectrum of drug discovery, from target identification through drug candidate selection and IND submission. CDT’s experienced drug hunters
work collaboratively with clients to assess a project’s scope and needs, and then provide a tailored strategy complete with quality execution.
999 Broadway Suite 305 Saugus MA 01906
CovalX is the leading CRO for protein interaction analysis by mass spectrometry. Our services include conformational epitope mapping by cross-linking (XL-MS), hydrogen deuterium exchange (HDX-MS), analysis of non-covalently bound protein complexes,
and therapeutic protein aggregates.
By bringing together modern label-free technology, application development know-how and sophisticated software, Creoptix offers a unique optical biosensor tool for binding kinetics. Engineered around our proprietary Grating-Coupled Interferometry
(GCI) technology, the Creoptix WAVEsystem delivers high-quality kinetic data across a broader range of samples than traditional SPR equipment.
16550 West Bernardo Drive Building 5, Suite 525
San Diego, California 92127
CrownBio is a preclinical solutions provider specializing in cardiovascular and metabolic diseases, including both rodent and nonhuman primate (NHP) models of NAFLD/NASH. Our unique continuum of translational platforms enable clients to take
strategic go/no-go decisions as they progress their therapeutic candidates through drug development, while predicting human efficacy and safety.
7171 RUE FREDERICK BANTING
Domain Therapeutics, a French and Canadian privately-held biopharmaceutical company, is using transmembrane and G Protein-Coupled Receptor (GPCR) targeting for the discovery and development of innovative therapeutics for the treatment of Central
Nervous System (CNS) diseases and cancer.
Chesterford Research Park
Domainex is a leading global provider of integrated drug discovery services, from protein expression through to nomination of pre-clinical drug candidates.
We provide the following:
Recombinant protein expression & purification
Assay development & screening
Fragment and virtual hit identification
Integrated medicinal chemistry (hit to candidate)
7 Deer Park Dr. Ste M-3
Monmouth Junction, NJ 08852
Enamine is a science-driven chemical company and provider of the world’s largest stock collections of building blocks and screening compounds. The company’s medicinal chemistry capabilities
are enhanced with on-site HTS, ADMET-DMPK and early preclinical studies to provide an easily customizable integrated service package.
11180 Roselle St. Suite D
Eurofins Discovery supports Drug Discovery through the combined expertise of Cerep, DiscoverX, Panlabs, Villapharma, and Selcia Drug Discovery. We offer a broad portfolio including medicinal and synthetic chemistry, in vitro pharmacology products
and services, cell-based phenotypic assays, ADME-Tox, in vivo drug safety and efficacy, custom proteins, and assay development services.
6-7 floor, Wing-B, NSL SEZ Arena, Plot6, Survey1, IDA, Uppal
Hyderabad, Telangana, 500039
Excelra’s data science solutions empower innovation in life sciences across the value chain from molecule to market. Our multifaceted scientific teams harmonize large
volumes of disparate unstructured data, analyze data using cutting-edge AI/ML technologies, and galvanize data-driven decisions to unlock operational efficiencies and accelerate drug development.
ExcepGen has invented a breakthrough technology capable of producing the most challenging targets and antigens. The platform has broad implications in drug and antibody discovery, scalable therapeutic protein production, new disease models,
and native small molecule targets. ExcepGen is reimagining therapeutics by using authentic human proteins.
Formulatrix is a lab automation company, established in 2002 to provide protein crystallization automation solutions. Since then, we have developed the next generation of liquid handlers using our patented microfluidic technology. We
supply software and robotic automation solutions to leading pharmaceutical companies and academic research institutions around the world.
GenScript Biotech Corp. is the world leader in biotechnology reagent industry. Established in 2002 in New Jersey, US, the company was the first to commercialize gene synthesis and successfully establish fully integrated capabilities for custom
peptide synthesis, protein expression and engineering, custom antibody development and engineering, and catalogue products.
75 Binney St, Cambridge, MA 02142
IBM Watson Health aspires to improve lives and give hope by delivering innovation, through data and cognitive insights, to address the world’s most pressing health challenges. The organization is working to use advanced technologies
to help people expand their knowledge base, improve their productivity, and deepen their expertise.
Iktos specializes in the development of AI solutions applied to medicinal chemistry and new drug design. Iktos' proprietary technology is based on deep learning generative models and enables to design molecules that are optimized to meet all
the success criteria of a small molecule discovery project.
ImmunoPrecise Antibodies Ltd. (IPA) is the preferred contract research organization for biotech and pharmaceutical researchers looking to discover and optimize successful therapeutic antibody candidates. Operating globally, IPA leverages advanced,
proprietery B cell selection, phage and hybridoma technologies and decades of experience to yield greater candidate diversity.
Parque Tecnologico de Bizkaia, Edificio 502, Planta 1
Innoprot provides products & technologies for multiplexing cell-based assays in drug discovery and development, covering applications in GPCRs, Tyrosin Kinase Receptors, Fibrosis, Neurodegenerative diseases or oncology. With a proprietary
technology for GPCR screening, Innoprot is able to analyze GPCR activation analyzing both signalling activation pathways (b-arrestin & G-Protein) simultaneously.
850 bvd Sebastien Brands
Illkirch Graffenstaden 67400
We are focused on identification of a drug primary target and clinical MOA directly in human with our label free technologies. Thanks to our technologies we Upgrade any drug on the market by improving efficacy and reducing side effects. The
novel compound is patented for the original and new indications.
3711 Market St., Suite 900
Integral Molecular is a research-driven biotech focused on discovering antibodies against challenging membrane protein targets using its MPS Antibody Discovery platform. MPS employs proprietary technologies including combined DNA+Lipoparticle
immunization for robust antibody elicitation, B-cell cloning for rare MAb isolation, membrane proteome profiling, and Shotgun Mutagenesis epitope mapping of conformational MAbs.
InterAx assists in GPCR drug candidate selection by integrating bioanalytical and computational pharmacology using mathematical models to address the complexity of drug-induced cellular signaling. InterAx closes the gap between lab experiments
and in-vivo-studies by streamlining processes of candidate design/selection, thereby significantly reducing risks, costs and duration of discovery and development.
The Mansion Chesterford Research Park
Little Chesterford, CB10 1XL
Isogenica develops and licenses advanced synthetic antibody libraries and display technologies, enabling its partners to accelerate their therapeutic antibody discovery programs. Both camelid single domain antibody and human conventional antibody
Fab libraries are available in industry standard phage display format, as well as proprietary CIS in vitro display technology.
#96, Industrial Suburb 2nd Stage, Yeshwantpur
Bangalore, Karnataka, 560 022
Through functional and/or integrated services ( Structural Biology, in-vitro and in-vivo Biology , Compchem, Chemistry, Medchem, DMPK and Toxicology, non GMP/GMP scale-up) the Jubilant Biosys team supports innovators in progressing their compounds to the clinical stage in the following TAs: Oncology, Metabolic Disorders, CNS, Pain, Inflammation, Fibrosis and Respiratory.
5119 Pegasus Court, Suite L-P
For more than 20-years, our team of protein problem-solvers has provided clients the full-continuum of protein-expression and manufacturing services---from gene to protein. We are focused on delivering timely, high-quality services, data-packages, and products to assist our clients, optimize productivity and mitigate risk in their discovery, development, and manufacturing programs.
Key Organics offers a wide variety of custom and contract services, as well as a large catalogue of high-quality Screening Compounds, Fragments, Biochemicals and Building Blocks under the ‘BIONET’ brand.
Labcyte, now a part of Beckman Coulter Life Sciences, is revolutionizing liquid handling. Echo® Liquid Handlers use sound to precisely transfer liquids without contact, eliminating the use of pipettes. Our customers work across a wide
spectrum of research, including drug discovery, genomics, proteomics, and personalized medicine. Visit labcyte.com or beckman.com.
We are a biotechnology company that develops enabling technologies for therapeutic, drug discovery, and research markets. We have established ourselves as a leader in ubiquitin and ubiquitin-like protein pathways by providing innovative research
tools. Additionally, our prokaryotic and eukaryotic protein expression platforms SUMOpro and SUMOstar are used worldwide.
617 Davis Drive Suite 100
Metabolon, Inc. is the world’s leading health technology company advancing metabolomics in precision medicine and life sciences research. Its Precision Metabolomics™ is a powerful technology for assessing health and
delivering biomarker discoveries, innovative diagnostic tests, and valuable data for genomics and population health initiatives.
Multispan, Inc. is a premier assay screening technology provider focusing primarily on cellular drug discovery research targeting GPCRs and beyond. It has created the industry’s largest, highly characterized, high quality GPCR-expressing
stable cell lines. The assay platform enables HTS and lead optimization applications in new drug discovery programs.
29-B King St E
Kitchener, Ontario N2G2K4
Nicoya uses nanotechnology to make OpenSPR™, the world’s only benchtop surface plasmon resonance instrument. OpenSPR is a user-friendly and low maintenance SPR solution being used in 25+ countries. With access to SPR technology
on your lab bench you can get the high quality data you need to accelerate your research.
3911 Sorrento Valley Blvd, Suite 110
Ligand's OmniAb® therapeutic antibody platforms produce highly diversified, fully human antibody repertoires optimized in vivo for manufacturability, therapeutic efficacy and reduced immunogenicity - Naturally optimized human antibodies®.
The single-license OmniAb offering is the industry's only with three species and multiple genetic backgrounds - 3 species, 1 license™.
F5-6 Blenheim House, Cambridge Innovation Park, Denny End Road
Optibrium provides software for drug design, optimisation and data analysis. Its lead product, StarDrop, is a comprehensive suite of integrated software enabling the seamless flow from the latest data through to predictive modelling and decision-making
regarding the next round of synthesis and research, improving speed, efficiency, and productivity of discovery.
Organix, is a CRO focused on Organic and Medicinal Chemistry. We provide Custom Synthesis of molecules in all structural classes. Organix owns and operates a state-of-the-art facility, staffed
by highly skilled Ph.D. organic chemists. Organix retains no rights to discoveries or inventions gathered in the course of the work.
Pelago are the leading experts in the Cellular Thermal Shift Assay (CETSA®), and provide specialist research services to the drug discovery industry based on all formats of CETSA.
We share your passion for science. Ensure your research successes with our product solutions for target-based discovery (GPCRs, kinase inhibitors, NASH), target engagement, targeted protein degradation, protein tagging, autophagy, antibodies
and immune-oncology. Learn about these and more at booth #103. Delivering more biologically relevant data. Let’s collaborate.
Proteome Sciences plc Hamilton House, Mabledon Place
We are a CRO specialising in the analysis of proteins and their associated PTM’s via advanced Mass Spectrometry. By using proprietary methodologies, we can detect up to 8,000 proteins per sample in Discovery mode and can offer
multiplexed assays of up to 100 proteins/sample in a GCLP accredited Targeted assay.
Rapid Novor is the world leader in antibody protein sequencing technology. Specializing in the field of mass spectrometry-based proteomics, the team has developed the REmAb™ platform to directly sequence the antibody proteins
without needing to access the cell line.
One Great Valley Parkway, Suite 2
Reaction Biology Corporation is an industry leader specializing in assay services for early-stage drug discovery. We offer kinase and epigenetic biochemical, biophysical, ion channel and cell-based assays. We offer assay reagents, including
high quality epigenetic proteins. Our mission is to be the premier provider of assay services to scientific organizations.
High Peak Business Park, Buxton Road
Chinley, High Peak, SK23 6FJ
Retrogenix provides a fast, accurate and effective solution for primary receptor identification and specificity screening of antibodies, protein ligands, CAR T cells, viruses and small molecules. Physiologically-relevant targets are identified
by screening for interactions against a comprehensive set of plasma membrane and tethered secreted proteins expressed in human cells.
Office #L4-01 & 02 SLN Terminus, Survey No. 133, Gachibowli Miyapur Road
Gachibowli, Hyderabad, Telangana 500032
Sai Life Sciences operates at four sites in India and offers services in biology, DMPK, toxicology, chemistry, early-phase scale-up, CMC and GMP manufacturing. We cover the entire R&D life cycle and are experienced in collaborating withy
a diverse range of clients, from start-up companies to big pharma.
120 West 45th Street 17th Floor
Schrödinger is a leading provider of advanced molecular simulations and enterprise software solutions that accelerate and increase the efficiency of drug discovery and materials design. Founded in 1990, Schrödinger has nearly
400 employees and operations across the world. For more information, please visit www.schrodinger.com.
9535 Waples Street, Ste 100
San Diego, CA, 92121-2993
SGI-DNA is a leading provider of synthetic biology solutions. We are committed to leveraging our automated DNA technologies into scientific solutions. From the world’s first DNA printer, BioXp™ 3200, to next-generation Gibson Assembly®
and Vmax™ protein expression, we able to integrate genomic workflows faster and more economically than traditional methods.
Medicilon offers fully integrated pharmaceutical services for the global scientific community. Since the founding of our company in 2004, our integrated services across biology, chemistry and preclinical services are uniquely designed to help
clients developing their research and discovery programs from the initial idea stage to the IND filing phase.
1400 Liberty Ridge Drive, Suite 101
Sino Biological offers a comprehensive set of premium quality reagents, all of which are made in-house, and quality guaranteed. Catalog products include proteins, antibodies, cDNA clones, ELISA kits, etc. It also provides customized services
for protein and antibody production, as well as many other Biopharmaceutical services.
Biocon Park , SEZ, Bommasandra Industrial Area - Phase-IV, Bommasandra-Jigani Link Road, Bengaluru, Karnataka 560099
Bangalore, Karnataka 560099
Syngene International is an innovation focused global discovery,development and manufacturing organization providing integrated scientific services to pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical
industries around the world. Syngene’s clientele include world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. For details, visit www.syngeneintl.com
Synthego is a leading provider of genome engineering solutions. Our automated, full stack genome engineering platform enables broader access to CRISPR to accelerate basic scientific discovery, uncover cures for diseases and develop novel synthetic
Suite 260 36 Washington Street
Wellesley hills, MA 02481
TargetMol is a global high-tech enterprise, specializing in chemical and biological research products and service to meet the research needs of global customers.We provide life-science reagents, inhibitors, activator, natural compounds for
laboratory and scientific use.
TetraGenetics is focused on the discovery and development of first-in-class biologic for autoimmune diseases, oncology and pain. The company has a breakthrough platform (TetraExpress™) for identifying antibodies targeting ion channels
and other transmembrane proteins. TetraGenetics is building a proprietary pipeline and working with major biotech companies for antibody discovery.
4 Blackfan Circle Suite 921
IPI aims to reignite the field of protein science as a means to realize the promise of genomics to advance biology and promote human health. We stimulate innovative research by developing and distributing open-source antibodies, protein research
tools and technologies, and lead therapeutics that will empower academic and industry scientists.
455 Mission Bay Blvd South Suite 545
San Francisco, California 94158
585 271 2700
Vaccinex, Inc. is a publicly traded clinical-stage biotechnology company engaged in the discovery and development of targeted biotherapeutics to treat serious diseases with unmet medical needs, including neurodegenerative diseases and cancer.
Additionally, Vaccinex has developed a proprietary mammalian cell based antibody discovery platform with unique multi-pass membrane target capabilities.
WuXi AppTec is a leading, global pharmaceutical and medical device open-access capability and technology platform company. As an innovation-driven and customer-focused organization, WuXi AppTec provides a broad and integrated portfolio of
services to help our partners shorten the discovery and development time through cost-effective and efficient solutions.
55 Cambridge Pkwy 8th Floor
WuXi NextCODE is a global genomic data and insights company. We serve the world’s leading life sciences companies by providing access to population-scale patient cohorts, NGS CLIA/CAP GCP labs globally, a team of leading A.I. and
genomic analysis experts for organizing, mining and sharing genomic and disease biology data.
X-Chem Pharmaceuticals is an innovator in DNA-encoded chemistry technologies with proprietary libraries of over 100 billion compounds. X-Chem has established partnerships with numerous leading pharmaceutical companies and has licensed
over 60 programs. X-Chem’s platform allows for lead compound generation targeting active/orthosteric site binders, PROTACs, covalent modulators and PPI disruptors.
ZoBio built its integrated fragment-based drug discovery engine on orthogonal technologies and 15 years of experience. The engine is based on high
throughput protein engineering, highly diverse fragment libraries, proprietary
biophysical technologies and complementary structural biology
approaches designed to enable the broadest possible target space.