Cambridge Healthtech Institute’s 8th Annual

Lead Generation Strategies

Small Molecule Drug Discovery Innovations

October 1-2, 2024


We’re at an exciting time in small molecule drug discovery, with many more and better ways to generate new chemical matter against a wider range of disease targets, including intracellular disease-related molecules that are part of protein-protein complexes. But having more ‘hits’ against the target deepens the challenge of choosing which have the best potential to be developed into drugs. Join your drug discovery colleagues at CHI’s Lead Generation Strategies conference to discuss best approaches for winnowing the winners. Through hit-to-lead case studies, presentations on new biophysical approaches, small group discussion sessions, poster and networking breaks, learn the latest on designing, finding and picking potential new orally bioavailable drug candidates.


Who should attend: Scientists, Resesearchers, Directors from Academics and Industry working in: Medicinal Chemistry, Discovery Chemistry, Biophysical Chemistry, Chemical Biology, Structure-Based Drug Design, Organic Chemistry, Biochemistry, Computational Chemistry


Coverage will include, but is not limited to:


  • Covalent approaches for gaining footholds on difficult drug targets
  • Innovations in hit-finding strategies such as DNA-Encoded Libraries (DEL), Fragment-Based Drug Discovery (FBDD), and Virtual Ligand Screening (VLS)
  • Integrating results from multiple lead-generation approaches (such as DEL, FBDD and VLS) for the same target
  • Applying orthogonal biophysical approaches for hit-to-lead decisions
  • Induced proximity strategies beyond degradation
  • Non-degrader glues & protein-protein interaction (PPI) stabilizers
  • Case studies on PPI-targeted compounds


The deadline for priority consideration is March 8, 2024.


All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


Opportunities for Participation:



For more details on the conference, please contact:

Anjani Shah, PhD

Senior Conference Director

Cambridge Healthtech Institute

Phone: (+1) 781-247-6252



For sponsorship information, please contact:

Kristin Skahan

Senior Business Development Manager

Cambridge Healthtech Institute

Phone: (+1) 781-972-5431