Cambridge Healthtech Institute’s 14th Annual

GPCR-Based Drug Discovery

Modulating G Protein-Coupled Receptors for New Therapeutic Options

September 18-19, 2019


G-protein coupled receptors (GPCRs), are proteins that span the cell membrane seven times and relay signals to inside the cell when bound by ligands specific to them such as certain hormones or neurotransmitters. Because GPCRs play roles in many physiological processes, they have been the target of medical therapeutics for decades. Their complexities in signaling though are still being unraveled and starting to be exploited for more targeted therapies. For example, therapeutics with fewer side effects are being sought by finding biased ligands of specific GPCRs that will activate or block the pathway of medical interest while not initiating less desirable signaling cascades that the GPCR also controls. Progress in biophysical techniques and cryo-electron microscopy have also aided targeted drug discovery against GPCRs by enabling biosensor-based screens or by helping elucidate structural features of GPCRs that guide structure-based drug design. Join colleagues and experts in the GPCR field from academics and industry at CHI’s well established GPCR-Based Drug Discovery conference to review advances in the field and discuss cutting edge topics impacting drug development against this very medically relevant class of drug targets.


Who should attend: Discovery Biologists, Structural Biologists, Membrane Protein Scientists, CNS Translational Researchers, Pharmacologists, Discovery Chemists, Medicinal Chemists, Biophysical Chemists, Computational Chemists, X-ray Crystallographers from academics, biotech and pharmacuetical companies.


Coverage will include, but is not limited to:

  • GPCRs in cancer and other diseases
  • Biased ligands or allosteric modulation of GPCRs, especially in the context of opiate alternatives
  • GPCR intracellular trafficking/ubiquitination/receptor desensitization and implications for drug discovery
  • GPCR oligomerization and cross-talk with other effectors
  • Structure-function insights from cryoEM and x-ray crystallography of GPCRs
  • Biophysical advances in studying GPCRs including NMR and Fragment-Based Drug Design applications


If you would like to submit a proposal to give a presentation at this meeting, please click here.


The deadline for priority consideration is February 27, 2019.


All proposals are subject to review by session chairmen and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


For more details on the conference, please contact:
Anjani Shah, PhD

Senior Conference Director

Cambridge Healthtech Institute

Phone: (+1) 781-247-6252


For partnering and sponsorship information, please contact:
Rod Eymael

Manager, Business Development

Cambridge Healthtech Institute

Phone: (+1) 781-247-6286

Premier Sponsors

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