Cambridge Healthtech Institute’s 5th Annual

Small Molecules Targeting RNA

Identifying New Drug Modalities and RNA Moieties for Therapeutic Intervention

September 26-27, 2023

Using small molecules to modulate RNA binding and function and get the desired biological outcome has generated much interest in drug discovery. However, understanding the structure and function of various RNA moieties present in the cell and the proteins they interact with-- and then identifying which one to target and how to target it has not been that easy. Challenges also exist in terms of determining the in vivo specificity, selectivity, and safety of these new small molecule modalities. Cambridge Healthtech Institute's conference on Small Molecules Targeting RNA will highlight some of the innovative approaches being pursued to identify and modulate the right RNA target.

Who should attend: Scientist in Molecular and Cellular Biology, Discovery Biology, Medicinal Chemistry, Lead Discovery, Drug Design, Computational Biology, Genomics, Assay Development and Screening.

Coverage will include, but is not limited to:

Tools for identifying the right RNA sequence or regulatory element for therapeutic intervention
Targeting pre-mRNA, mRNA, tRNA, and RNA binding proteins
Identifying pathways (splicing, translation, transcription) for RNA modulation
Designing small molecule libraries specific to RNA
Determining the structural and physicochemical constraints for RNA-ligand interactions
Strategies for characterization and lead optimization of RNA-targeting small molecules
Biophysical/phenotypic screening for identifying and quantifying RNA binding
Utilizing artificial intelligence and machine learning for RNA drug discovery
Understanding RNA epigenetics
Challenges in designing small molecules that bind RNA

The deadline for priority consideration is March 17, 2023.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

Opportunities for Participation: