Cambridge Healthtech Institute’s 6th Annual

Disease Modeling  

Developing, Validating, Scaling, and Automating Physiologically Relevant Disease Models

September 16-17, 2020


Inadequate representation of the human tissue environment during a preclinical screen can result in inaccurate predictions of a drug candidate’s effects. Thus, investigators are searching for preclinical models that closely resemble original tissue for predicting clinical outcome. With advances in reprogramming and differentiation technologies, as well as with the recent availability of gene editing approaches, we are finally able to create more complex and phenotypically accurate models that span all therapeutic areas. At Cambridge Healthtech Institute's 6th Annual Disease Modeling conference, we will discuss the next generation of models, as well as strategies to overcome common bottlenecks, such as standardization, scaling, and workflow integration.

Preliminary Agenda


Recommended Short Course*

SC7: Intro to OOAC and Bioprinting for Disease Modeling - Detailed Agenda

*Separate registration required.

MOVING TOWARDS A 3D PHYSIOLOGICALLY RELEVANT CELLULAR MODEL

Adult Stem Cell Organoids: A Patient in the Lab

Robert Vries, PhD, CEO, Hubrecht Organoid Technology (HUB)

Understanding Donor-to-Donor Variability in Healthy Human Gut-Derived Organoids

Linda Lieberman, PhD, Principal Scientist, Merck Exploratory Science Center

 

HOW TO SCALE UP 3D MODELS FOR HTS OR UHTS

3D Enteroid-Derived “Gut-in-a-Dish” Model for Developing Personalized Therapies for Chronic Inflammatory Diseases

Soumita Das, PhD, Associate Professor, Department of Pathology, Chief Scientific Director, HUMANOID Center of Research Excellence (CoRE), University of California, San Diego

3D Models of Brain Cancer for Precision Medicine Therapeutic Profiling

Virneliz Fernandez Vega, Scientific Associate, Molecular Medicine, Scripps Research

Development of a Miniaturized 3D Organoid Culture Platform for Ultra-High-Throughput Screening (uHTS)

Yuhong Du, PhD, Associate Professor, Department of Pharmacology and Chemical Biology, Associate Director, Emory Chemical Biology Discovery Center (ECBDC), Emory University School of Medicine

 

UTILIZING iPSC TO MODEL DISEASES AND EXPLORE TOMORROW’S THERAPEUTICs

FEATURED PRESENTATION: Generation, Validation & Application of iPSC Models in Early Discovery

Lisa Mohamet, PhD, Scientific Leader, Drug Design & Selection, GSK

 

Talk Title to be Announced

Blake Anson, PhD, Vice President, Business Operations, StemoniX

 

Presentation to be Announced

BIOENGINEERED BLOOD-BRAIN BARRIER MODELS

Reconstruction of the Human Blood-Brain Barrier in vitro Reveals the Pathogenic Mechanisms of APOE4 in Cerebral Amyloid Angiopathy

Joel Blanchard, PhD, Postdoctoral Fellow, Picower Institute for Learning and Memory, MIT

3D Alzheimer’s Disease (AD) Model for Studying the Blood-Brain Barrier Dysfunctions in Ad

Yoojin Shin, PhD, Postdoctoral Fellow, Mechanical Engineering, Roger Kamm’s Lab, MIT

Corning_NewRediscovering the Potential of 3D Cell Culture: From Development to Disease Modeling

Christopher Suarez, PhD, Field Applications Manager, Corning Life Sciences, Corning Incorporated


LUNCHEON PRESENTATION: Structural Maturation in the Development of hiPSC-Cardiomyocyte Models for Preclinical Safety, Efficacy, and Discovery

Nicholas Geisse, PhD, CSO, NanoSurface Biomedical

 

BIOENGINEERED MODELS FOR DRUG DISCOVERY AND DEVELOPMENT

KEYNOTE PRESENTATION: PhysioMimetics: Integration of Systems Biology with Organs-on-Chips for Drug Development

Linda Griffith, PhD, School of Engineering Professor of Teaching Innovation, Biological Engineering, and Mechanical Engineering, Massachusetts Institute of Technology



For more details on the conference, please contact:
Mary Ann Brown
Executive Director, Conferences
Cambridge Healthtech Institute
Phone: (+1) 781-972-5497
Email: mabrown@healthtech.com

For partnering and sponsorship information, please contact:
Rod Eymael
Manager, Business Development
Cambridge Healthtech Institute
Phone: (+1) 781-247-6286
Email: reymael@healthtech.com