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Listen to the Podcast below or view the Transcript here

Advances and Challenges in the Discovery and Development of Histone Demethylase Inhibitors

with Dr. Christopher Schofield, Head of Organic Chemistry in the Chemistry Research Laboratory at the University of Oxford

CHI interviews Dr. Christopher Schofield, Head of Organic Chemistry in the Chemistry Research Laboratory at the University of Oxford, regarding his current work designing new demethylase inhibitors, current challenges, and his outlook for continued development in this space.

Discussion Questions Include:

• How have you have seen this space evolve over the past few years?
• What are some demethylase targets currently being pursued by Medicinal Chemists?
• Can you please describe some of the work currently being conducted in your lab toward the discovery of new demethylase inhibitors?
• What challenges have been encountered designing small molecule histone demethylase inhibitors?
• How do you see this research evolving over the next few years?

For more information, please visit http://discoveryontarget.com/dot/archives