Can (Martin) Zhang, MD, PhD, Assistant Professor of Neurology, Harvard Medical School, Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital
Alzheimer’s disease (AD) is an ageing-related neurodegenerative disorder. It is the primary cause of dementia in the elderly and presently no effective therapeutics are available to modulate disease progression. Genetics have identified not only mutations in specific genes that are linked to the familial early onset form of AD, but also the cause(s) of the more typical late onset form of the disease. Studies have identified new molecular mechanisms and modifiable risk factors of AD, which may enable the development of effective interventions to prevent or cure the disease. Emerging research has shown that the disease can be potentially prevented; and an increasing number of researchers are developing therapies that can modify disease pathology or risk. This talk will be focused on recently identified molecular mechanisms of AD, and translational potentials of developing effective therapeutics of AD.