Targeting the Ubiquitin-Proteasome System

The ubiquitin-proteasome system (UPS) is a well-controlled, selective mechanism for intracellular protein degradation and turnover. New understanding of the role and molecular mechanisms involved in the dysregulation of the UPS has led to its emergence as a key regulator of protein function and stability. Although implicated to play a role in cancer, CNS, infectious diseases and more, the multi-step processes involved, and the diversity of substrates makes it difficult to target the UPS. However, in recent years, the development of high-quality chemical probes and assay technologies has turned it into one of the most exciting targets for discovering novel drugs. In the UPS, the ligases and deubiquitinases (DUBs) have recently attracted a lot of attention as possible targets for clinical intervention. Cambridge Healthtech Institute’s Targeting the Ubiquitin-Proteasome System conference will bring together a diverse group of chemists and biologists to discuss the promise and challenges in modulating the UPS. This conference will be preceded by a symposium that focuses on targeting autophagy pathways and will draw on some of the synergies between these two areas of research.


Who should attend: SCIENTISTS and EXECUTIVES from Pharma, Biotech, Academia, Government, Contract Research Labs and Technology Providers involved in target ID & validation, discovery biology, cancer biology, immunology, discovery chemistry, biochemistry, molecular & cell biology, phenotypic screening, assay development, chemical biology, and other areas related to early drug discovery & development.


Coverage will include, but is not limited to:

  • Emerging approaches for targeting the ubiquitin cascade
  • New probes and inhibitors targeting DUBs, E2 and E3 ligases
  • Novel bivalent inhibitors for hijacking the UPS and targeted protein degradation
  • Targeting ubiquitin-like molecules
  • Exploring PROTACS, hydrophobic tagging, and strategies to disrupt protein-protein interactions
  • New tools and assays to study and modulate the UPS biology
  • Translating lessons learned from kinase drug discovery
  • Tackling challenges with specificity and toxicity


If you would like to submit a proposal to give a presentation at this meeting, please click here.


The deadline for priority consideration is March 21, 2018.


All proposals are subject to review by session chairmen and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


For more details on the conference, please contact:
Tanuja Koppal, PhD

Conference Director

Cambridge Healthtech Institute



For partnering and sponsorship information, please contact:
Rod Eymael

Manager, Business Development

Cambridge Healthtech Institute

Phone: (+1) 781-247-6286