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The RNAi for Functional Genomics Screening will cover the latest in the use of RNA interference (RNAi) screens for identifying and validating drug targets and exploring unknown cellular pathways. It will cover everything from assay design to data analysis for the use of in vitro and in vivo siRNA (small interfering RNA) and shRNA (short hairpin RNA) screens. There is growing interest in combining RNAi screens with gene editing, chemical genomics, overexpression studies and phenotypic screens, which will all be discussed here. Screening experts from industry and academia will share their experiences leveraging the utility of these diverse screening platforms for a wide range of applications.

Preliminary Agenda


EXPLOITING NEW SCREENING PARADIGMS

Harnessing High Throughput RNAi for Target Identification Utilizing 3D cell Culture Models

Geoffrey Bartholomeusz, Ph.D., Associate Professor and Director, siRNA Core Facility, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center

Development of Physiologically Relevant Assay Platforms to Probe Various Disease Pathologies

Madhu Lal-Nag, Ph.D., Team Leader, RNAi Screening, National Center for Advancing Translational Sciences, National Institutes of Health

Talk Title to be Announced

Scott Martin, Ph.D., Group Lead, Functional Genomics, Genentech Inc.


EXPLORING NEW TARGETS & PATHWAYS

Identifying Regulatory Interactions Among Genes Linked to Alzheimer’s Disease

Michael Ollmann, Ph.D., Principal Scientist, Genome Analysis Unit, Amgen Inc.

RNAi for Rare Disease Drug Discovery; Signal or Noise?

Christopher Gibson, Ph.D., Co-Founder and CEO, Recursion Pharmaceuticals


GETTING THE MOST OUT OF YOUR DATA

Development and Application of CARD, a Comprehensive Integrated Web-Based Platform for Analysis of RNAi Screening Data

Iain Fraser, Ph.D., Investigator, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health

3D Phenotypic Screening for Target Identification and Drug Discovery

Arvind Rao, Ph.D., Assistant Professor, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center

The Path From Arrayed RNAi to Arrayed CRISPR Screens: Lessons Learned and Challenges

Eugen Buehler, Ph.D., Group Leader, Informatics, National Center for Advancing Translational Sciences, National Institutes of Health


COMPLEMENTARY USE OF RNAi AND GENE EDITING

Pooled shRNA, Arrayed siRNA and CRISPR-Cas9: Three Essential Tools Towards Understanding Gene Function in Cancer and Disease Biology

Ralph Garippa, Ph.D., Director, RNAi Core Facility, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center

Parallel shRNA and CRISPR/Cas9 Screens Reveal Biology of Stress Pathways and Identify Novel Drug Targets

Michael Bassik, Ph.D., Assistant Professor, Department of Genetics, Stanford University

Screening the Kinome: Lessons From Using Functional Screens in Glioblastoma Stem Cells

Brent Cochran, Ph.D., Professor, Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine



For more details on the conference, please contact:
Tanuja Koppal, Ph.D.
Conference Director
Cambridge Healthtech Institute
E: tkoppal@healthtech.com 

For partnering and sponsorship information, please contact:
Jon Stroup
Sr. Business Development Manager
Cambridge Healthtech Institute
T: (+1) 781-972-5483
E: jstroup@healthtech.com 

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2014 Discovery on Target Brochure  


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2014 BROCHURE 

 PREMIER SPONSORS 

Cellecta 

Molecular Sensing 

Rosa Drug Development Advisors
 

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VIEW MEDIA PARTNERS 


SPONSORSHIPS & EXHIBITS 

The exhibit hall was sold out in 2014, so please contact us early to reserve your place. To customize your sponsorship or exhibit package for 2015, contact:

Jon Stroup
Sr. Business Development Manager
781-972-5483
jstroup@healthtech.com 


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HOTEL & TRAVEL 

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