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Targeting The Unfolded Protein Response - A New Avenue for Drug Discovery

Claudio Hetz, Ph.D., Professor, Institute of Biomedical Sciences, University of Chile; Principal Investigator, Laboratory of Cellular Stress and Biomedicine, Adjunct Professor, School of Public Health, Harvard University

CHI interviews Dr. Claudio Hetz, Professor in the Institute of Biomedical Sciences, and Principal Investigator in the Laboratory of Cellular Stress and Biomedicine at the University of Chile about the rapidly evolving drug discovery space of targeting the unfolded protein response (UPR) - particularly for cancers and neurodegenerative diseases.

Discussion questions include:

• Why has targeting components of the UPR emerged as a viable therapeutic strategy? (What are some of the recent critical discoveries that have propelled this field forward?)
• What are emerging and promising therapeutic targets within the UPR and why?
• What are some of the current challenges surrounding targeting the UPR?
• You are giving a lecture during the upcoming Targeting the Unfolded Protein Response meeting, September 23-24 in Boston. Can you tell us a little about your work and what you hope to convey to attendees during the conference?
• What are people within this space just now starting to think about? In other words, where will the greatest attention be over the next few years within this space?

Find more information at www.DiscoveryOnTarget.com/