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The microbiome R&D is an emerging area of science that is starting to prove its importance. A PubMed search on the term “human microbiome” yielded 300 citations in 2003, 4,498 citations in 2013, and 20,223 citations in 2016. Basic and applied biomedical research from the Human Microbiome Project and other independent studies prove that a disruption of a stable microbiome ecosystem results in dysbiosis. This imbalance leads to chronic disease and health conditions like inflammation, metabolic disorders, gut disorders, obesity, Type 2 Diabetes, autoimmune disorders, inflammatory bowel disease, neurodevelopmental disorders and more. There is great promise in correlating the microbiome compositions with these diseases and using the microbiome as a tool for therapeutic development.

This two-part meeting provides interactive sessions and panel discussions with leading researchers and thought leaders who will discuss how their work in this field has and will continue to have tremendous impact in generating personalized diagnostics and therapeutics to improve disease treatment and human health.

Part One of the Targeting the Microbiome Track, taking place September 20-21, 2016, will discuss the underlying mechanisms of the disease. We’ll explore scientific-based case studies of the interaction between the microbiome and the immune system, particularly pathways being activated. We will also explore the future of translational medicine as it pertains to the microbiome area and investment/collaboration opportunities.

AUDIENCE PROFILE
We expect an audience of approximately 100-125 attendees comprised of the following profile: Directors, Managers, Researchers, and Scientists from Pharma, Biotechs, Academia, Government and Healthcare Organizations working in Microbiology, Immunology, Clinical Pathology, Metagenomics, Food Science & Technology, Genome Sciences & Systems Biology, Computational Biology, Pathology, Microbial Genomics, Molecular Biology, and Therapeutic Innovation.

Final Agenda


RECOMMENDED ALL ACCESS PACKAGE:

• September 19 Short Course: Designing Peptide Therapeutics for Specific PPIs

• September 19 Short Course: Using IP Landscape Studies to Improve Your Confidence While Navigating a Crowded IP and Technology Space

• September 20-21 Conference: Targeting the Microbiome - Part 1

• September 21-22 Conference: Targeting the Microbiome - Part 2


Day 1 | Day 2 | Download Brochure


Tuesday, September 20

7:00 am Registration Open and Morning Coffee

DYNAMICS OF THE MICROBIOME ON HEALTH AND DISEASE

8:05 Chairperson’s Opening Remarks

8:20 KEYNOTE presentation: ELUCIDATING MICROBIOME ROLE AND FUNCTION IN HUMAN HEALTH AND DISEASE USING AN INTEGRATED “-OMICS” APPROACH

Niels Klitgord, Ph.D., Bioinformatician, Human Longevity, Inc.

Human health associations with the microbiome are rampant, finding links in areas ranging from human development to neurology. However, the mechanistic understanding of these associations is mostly lagging, confounding diagnosis and development of treatments. We present an overview of our on-going effort to elucidate microbiome role in human health and disease that is based on whole genome sequencing and analysis of over 3,000 microbiome samples from well phenotyped cohorts.

8:50 Quantitative Prediction of Microbiota Dynamics for Development of Bacteriotherapies

Georg K. Gerber, M.D., Ph.D., MPH, Assistant Professor of Pathology, Harvard Medical School; Co-Director, Massachusetts Host-Microbiome Center; Associate Pathologist, Brigham and Women’s Hospital Center for Advanced Molecular Diagnostics

I will present our work on discovery of networks of commensal bacteria protecting against Clostridium difficile and prediction of stability of configurations of bacteria in an immune-modulating probiotic cocktail. This work leverages our new computational framework, Microbial Dynamical Systems INference Engine (MDSINE), which infers dynamical systems models from noisy microbiome sequencing time-series datasets and predicts future behaviors of the microbiota using novel Bayesian machine learning methods. Results of in silico and gnotobiotic mouse experiments that validate MDSINE’s performance will be shared. By attending this talk, attendees will: (1) gain an understanding of the necessity of considering the microbiota as a dynamical system when developing bacteriotherapies, (2) gain insight into a novel computational method for analyzing longitudinal microbiome studies that provides new quantitative measures of microbiota dynamics, (3) gain an understanding of how this method can be applied to discover and characterize new bacteriotherapies, with our work on Clostridium difficile and inflammatory bowel disease bacteriotherapies as examples.

9:20 Fecal Microbiota Transplantation for the Treatment of Recurrent Clostridium Difficile Infection and Beyond

Jessica R. Allegretti, M.D., MPH, Attending Gastroenterologist, Director of Clinical Trials and Director of the Fecal Transplant Program for Recurrent Clostridium Difficile, Brigham and Women’s Hospital Crohn’s and Colitis Center

9:50 Grand Opening Coffee Break in the Exhibit Hall with Poster Viewing

10:35 Skin Microbiome Editing by Specific Targeting Probiotic Microbes

Chun-Ming Eric Huang, Ph.D., Professor, Division of Dermatology, University of California San Diego

11:05 Exploring Microbiome in Metabolic Diseases

Deepak K. Rajpal, D.V.M., Ph.D., Director, Computational Biology, GlaxoSmithKline

Metabolic diseases, especially type 2 diabetes and obesity, are growing global healthcare concerns. Various studies have highlighted the role of gastrointestinal microbial communities in metabolic health and disease. We will provide a brief overview of the gut microbiome, its putative role in metabolic diseases and the emerging data in this space.

11:35 Data and Digital Tools for the Microbiome – An Emerging Field in Autoimmune Disease

Bonnie Feldman, D.D.S., MBA, Digital Health Analyst and Chief Growth Officer, DrBonnie360

New research shows an association between changes in the microbiome in Lupus and Rheumatoid arthritis. With the convergence of large population data sets and personal data we are beginning to make progress in research, development and clinical trials in autoimmune disease. This talk will highlight new companies using data and digital tools to improve our understanding and treatment of autoimmunity.

12:05 pm Sponsored Presentation (Opportunity Available)

12:35 Session Break

12:45 Luncheon Presentation (Sponsorship Opportunity Available) or Lunch on Your Own

1:25 Refreshment Break in the Exhibit Hall with Poster Viewing

DYNAMICS OF THE MICROBIOME ON HEALTH AND DISEASE

2:05 Chairperson’s Remarks

Bonnie Feldman, D.D.S., MBA, Digital Health Analyst and Chief Growth Officer, DrBonnie360

2:15 Metraproteome Display: A Novel Target Discovery Paradigm for Microbiome Related Autoimmune Diseases

Michael Hust, Ph.D., Professor, Department of Biotechnology, Technische Universität Braunschweig

Display is a novel but already proven approach for the identification of microbial biomarkers which can neither be found by classical MS based proteomics nor by all cDNA based methods. Metaproteome Display allows the selective display of microbiota-derived whole genome ORFs on the surface of phage particles and functional screening for biomarker candidates by affinity binding to antibodies from matching donor sera. By functionally analysing entire ORFeomes, we already discovered novel Biomarkers of a number of microbial pathogens and bowel-disease metagenomes.

2:45 Precise Characterization of and Selective Removal in Bacterial Communities

Bruno Marchon, Ph.D., CTO, EpiBiome

Rich bacterial communities are widespread: Our gut flora is necessary to our well-being, and food preservation has long relied on “good” bacteria to help ward off pathogens. At EpiBiome, we are developing sustainable alternatives to antibiotics, while devising novel technologies to better characterize bacterial populations. These approaches will provide healthcare, agriculture and food producers with better tools to help them deliver better services and products.

3:15 Sponsored Presentation (Opportunity Available)

3:45 Refreshment Break in the Exhibit Hall with Poster Viewing and Poster Competition Winner Announced

4:25 KEYNOTE PRESENTATION: DISCOVERING AND MODELLING PATHOGEN SHARING IN HUMANS, GORILLAS AND LIVESTOCK IN UGANDA

David T.S. Hayman, Ph.D., Senior Lecturer in Veterinary Public Health, Co-Director, mEpiLab, OIE Collaborating Centre Infectious Disease Research Centre, Hopkirk Research Institute, Massey University, New Zealand

How do humans become infected with a virus from another species? The moment of cross species transmission (aka ‘spillover’) is rarely observed, but culture free next-generation sequencing metagenomic studies allow us new insights into transmission and to test specific hypotheses, including whether pathogen sharing is determined by host relatedness (phylogeny), contact rates, or pathogen traits. Our studies in Africa on people, livestock and wildlife will allow us to address some of these key questions regarding how infections cross the species barriers.

5:25 Welcome Reception in the Exhibit Hall with Poster Viewing

6:25 End of Day

Day 1 | Day 2 | Download Brochure


Wednesday, September 21

7:30 am Registration Open and Morning Coffee


Innovation, Investment, and Collaboration

8:00 Chairperson’s Opening Remarks

8:10 Panel Discussion: From Microbiome to Market

Keith F. Batchelder, M.D., CEO and Founder, Genomic Healthcare Strategies (Chairperson/Moderator)

David Berry, M.D., Ph.D., General Partner, Flagship Ventures

Sacha Mann, Principal, Inventages Venture Capital

Bernat Olle, Ph.D., CEO, Vedanta Biosciences, Inc.

Greg Sieczkiewicz, J.D., Ph.D., Chief IP Council, MPM
Cameron Wheeler, Ph.D., Principal, Deerfield Management 

This Microbiome to Market panel discussion serves as a critical bridge between Part One and Part Two of the Targeting the Microbiome Program. The discussion is appropriate for those working in academic research or science who are thinking about putting a company together or at least thinking about the translation piece. The discussion is also appropriate for companies who have already harnessed microbiome research for a therapeutic area or disease condition to learn the kinds of business and financial models that investors find attractive. Leading investors will gather to discuss the areas of the microbiome they are looking at and why. We will explore the global scope of microbiome and successful collaboration, reimbursement, and business investment models between science, business, healthcare, and government in bringing live microbial products to market. We will also discuss balancing venture activities, external R&D, and long-term market opportunities. Join us for a lively and interactive discussion of the how’s and what’s of bringing your microbiome product or service to market.

9:40 Coffee Break in the Exhibit Hall with Poster Viewing

10:25 PANEL DISCUSSION: Building Effective Partnership Models in Product Development and Commercialization

Wade Blair, Ph.D., Executive Director, Infectious Disease and Vaccines, Merck
John Hambor, Ph.D., Director, Research Beyond Borders, Boehringer Ingelheim

Additional Panelists to be Announced 

Identifying and integrating strategic partnership relationships effectively into your overall business strategy is critical and essential to move the business forward and deliver results. This panel discussion will discuss the skills needed for organizations to collaborate, develop, and commercialize novel therapeutics. Join us for a lively and interactive discussion of the why’s and how’s in maintaining and expanding a productive alliance in the face of a complex collaboration agreement, organizational and market driven changes.

11:25 Enjoy Lunch on Your Own



2:40 Refreshment Break in the Exhibit Hall with Poster Viewing

3:20 End of Conference



Day 1 | Day 2 | Download Brochure

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Targeting the Microbiome - Part 2 Header

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Final Agenda Now Available


 PREMIER SPONSOR

Cellecta

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SPONSORSHIPS & EXHIBITS

The exhibit hall was sold out in 2015, so please contact us early to reserve your place. To customize your sponsorship or exhibit package for 2016, contact:

Jon Stroup
Sr. Business Development Manager
781-972-5483
jstroup@healthtech.com

 

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IPR-Special-Report-Packages  

SEPTEMBER 19 SYMPOSIA:

Next-Generation Histone Deacetylase Inhibitors

Strategies for Tackling Rare Genetic Diseases

Understanding CRISPR: Mechanisms and Applications

Autoimmunity – Small Molecule Approaches

NK Cell-Based Cancer Immunotherapy

Medical Dermatology Therapeutic R&D and Technical Innovation

CONFERENCES

SEPTEMBER 20-21

Targeting Histone Methyltransferases and Demethylases

Targeting the Ubiquitin Proteasome System

Targeting the Microbiome
– Part 1

GPCR-Based Drug Discovery - Part 1

Advances in Gene Editing and Gene Silencing – Part 1

Gene Therapy Breakthroughs

Antibodies Against Membrane Protein Targets – Part 1

Targeting Cardio-Metabolic Diseases

Targeting Ocular Disorders

SEPTEMBER 21-22

Targeting Epigenetic Readers and Chromatin Remodelers

Kinase Inhibitor Discovery

Targeting the Microbiome
– Part 2

GPCR-Based Drug Discovery - Part 2

Advances in Gene Editing and Gene Silencing – Part 2

Translating Cancer Genomics

Antibodies Against Membrane Protein Targets – Part 2

Metabolomics in Drug Discovery

TRAINING SEMINAR: Data Visualization

SHORT COURSES*

Monday, September 19
8:00 - 11:00 am

(SC1) Immunology Basics for Chemists

(SC2) Designing Peptide Therapeutics for Specific PPIs

(SC3) Phenotypic Screening and Chemical Probe Development

(SC4) Medical Dermatology Therapeutic R&D and Technical Innovation - Part 1

Monday, September 19
2:00 - 3:00 pm

(SC5) GPCR Structure-Based Drug Discovery

(SC6) RNA as a Small Molecule Drug Target

(SC7) Using IP Landscape Studies to Improve Your Confidence

(SC8) Medical Dermatology Therapeutic R&D and Technical Innovation - Part 2

Monday, September 19
3:30 - 6:30 pm

(SC9) Targeting of GPCRs with Monoclonal Antibodies

(SC10) Introduction to Targeted Covalent Inhibitors

(SC11) Contact Lens Drug Delivery Systems

(SC12) Introduction to Gene Editing

Monday, September 19
7:00 - 9:30 pm

(SC13) Convergence of Immunotherapy and Epigenetics for Cancer Treatment

Wednesday, September 21
7:00 - 9:30 pm

(SC14) Cancer Metabolism: Pathways, Targets and Clinical Updates

(SC15) Introduction to Allosteric Modulators and Biased Ligands of GPCRs

(SC16) Functional Screening Strategies Using CRISPR and RNAi

(SC17) Challenges and Opportunities in DNA Methyl Transferase (DNMT) Inhibitors as Therapeutics