Cambridge Healthtech Institute’s 4th Annual
Antibodies against Membrane Protein Targets
Part One: Antigen Optimization and Antibody Discovery

September 20-21, 2016
Part of the 14th Annual Discovery on Target Conference

As the pharmaceutical and biotech industries increasingly shift attention to biologics, much more attention is being paid to the prospect of membrane-bound proteins as drug targets for antibodies and other protein scaffolds. For the large GPCR and ion channel target classes, biologics offer improved selectivity, an alternative for targets with known function that have not been amenable to small molecule drugs and the potential for using antibodies for the targeted delivery of therapeutics. However, for the field to advance, fundamental challenges in optimizing antigen quality and presentation, discovery methodologies, protein engineering and target identification must be resolved.

This two-part meeting provides a forum in which discovery biologists and protein engineers can come together to discuss next generation strategies and technologies that will allow antibody- and alternate scaffold-based therapeutics directed against these target families to advance into the clinic and beyond.

Part One:

The first meeting in the set, Antigen Optimization and Antibody Generation, offers a comprehensive examination of state of the art approaches for producing high quality membrane protein antigens and the display and immunization strategies that can be applied to discover binders with functional activity against GPCR and ion channel targets.

Expression and Production Optimization of Membrane Protein Antigens

  • Antigen engineering
  • Best practices for generating high quality antigens
  • Improving “shots on goal”; experimentation with multiple systems and variants
  • Presentation, solubilization and stabilization
  • Selection of expression and purification systems

Antibody Generation and Engineering Strategies

  • Display technologies for complex targets
  • Emerging immunization strategies
  • Emerging in vitro systems for antibody generation
  • New animal strains for immunizations
  • Reagents to optimize affinity maturation

New Technologies for Discovery of Antibodies against Membrane Protein Targets

  • Antigen-specific cell sorting
  • Cell surface panning
  • Next generation sequencing
  • Panning against tissues
  • Single cell antibody cloning and sequencing

If you are interested in speaking, please click here.

Click here to register for a special early-bird discounted rate.

The deadline for submission is March 4, 2016.

All proposals are subject to review by the Scientific Advisory Committee to ensure the highest quality of the conference program. Please note that due to limited speaking slots, preference is given to pharmaceutical and biotech companies, regulators and those from academia. Additionally, vendors/consultants who provide products and services to these biopharmaceutical companies are offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

For questions or suggestions about the meeting, please contact:
Kent Simmons
Cambridge Healthtech Institute
T: (+1) 781-972-9199

For sponsorship and exhibit sales information including sponsored podium presentations, contact:
Jon Stroup
Senior Manager, Business Development
Cambridge Healthtech Institute
T: (+1) 781-972-5483