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As the pharmaceutical and biotech industries increasingly shift attention to biologics, much more attention is being paid to the prospect of membrane-bound proteins as drug targets for antibodies and other protein scaffolds. For the large GPCR and ion channel target classes, biologics offer improved selectivity, an alternative for targets with known function that have not been amenable to small molecule drugs and the potential for using antibodies for the targeted delivery of therapeutics.

The second conference, Structural Analysis, Characterization and Development, explores structural, biochemical and biophysical studies used to understand the behavior of membrane protein targets in native and inhibited or activated states – and then considers issues related to the preclinical and clinical development of antibodies and other biologics as drug products against these challenging targets.

Preliminary Agenda


STRUCTURAL BIOLOGY STUDIES TO SUPPORT DEVELOPMENT OF ANTIBODIES AGAINST MEMBRANE PROTEIN TARGETS

Keynote Presentation: Antibody Epitopes on G Protein-Coupled Receptors Mapped with Genetically Encoded Photoactivatable Cross-Linkers

Thomas P. Sakmar, M.D., Richard M. & Isabel P. Furlaud Professor, Laboratory of Chemical Biology & Signal Transduction, The Rockefeller University

Sodium Channel Structures in Complex with Drugs

Bonnie Ann Wallace, Ph.D., Professor, Institute of Structural and Molecular Biology, Birkbeck College, United Kingdom

Structure of a Human Ion Channel

Christopher Koth, Ph.D., Senior Scientist, Structural Biology, Genentech

Use of Antibody Fragments to Solve GPCR Structures

Andrew Kruse, Ph.D., Principal Investigator, Biological Chemistry and Molecular Pharmacology, Harvard Medical School


CHARACTERIZATION OF MEMBRANE PROTEIN TARGETS

Back Scattering Interferometry for Characterization of Membrane Protein Targets

Darryl J. Bornhop, Ph.D., Professor, Chemistry, Vanderbilt University

Characterization Studies for ShK Toxin Peptide against Kv1.3

Christine Beeton, Ph.D., Associate Professor, Molecular Physiology and Biophysics, Baylor College of Medicine

Binding Analysis of Membrane Protein Targets with Label-Free Analytical Biosensor

Wei Wang, Ph.D., Senior Scientist, Therapeutic Discovery, Amgen

Strategies for Optimizing and Characterizing MAbs against Multi-spanning Membrane Protein Targets

Benjamin Doranz, Ph.D., President & CSO, Integral Molecular, Inc.

Pharmacological Characterization of Anti-CXCR2 Nanobodies

Michelle Bradley, Ph.D., former Investigator, Molecular Pharmacology, Respiratory Disease Area, Novartis Institutes for Biomedical Research (NIBR), United Kingdom


BIOLOGIC DRUG PRODUCT DEVELOPMENT FOR MEMBRANE PROTEIN TARGETS

Development of Antibody Therapeutics to TrpA1

Ki-Jeong Lee, Ph.D., Senior Scientist, Amgen

Targeting GPCRs with Antibodies with Long CDR3

Vaughn Smider, Ph.D., CSO, Sevion Therapeutics

Fully Human Antagonistic Antibodies against CCR4 Potently Inhibit Cell Signaling and Chemotaxis

Alexander Duncan, Ph.D., Vice President, Preclinical Development, Agenus

Identification of Epitopes for the Development of Selective, Functional Antibodies Targeting Sodium Ion Channels

Gregory Babcock, Ph.D., Executive Director, Research, Visterra, Inc.



For questions or suggestions about the meeting, please contact:
Kent Simmons
Program Director
Cambridge Healthtech Institute
T: 207-869-9199
E: ksimmons@healthtech.com 

For sponsorship and exhibit sales information including sponsored podium presentations, contact:
Jon Stroup
Sr. Business Development Manager
Cambridge Healthtech Institute
T: (+1) 781-972-5483
E: jstroup@healthtech.com 

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2014 Discovery on Target Brochure  


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2014 BROCHURE 

 PREMIER SPONSORS 

Cellecta 

Molecular Sensing 

Rosa Drug Development Advisors
 

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SPONSORSHIPS & EXHIBITS 

The exhibit hall was sold out in 2014, so please contact us early to reserve your place. To customize your sponsorship or exhibit package for 2015, contact:

Jon Stroup
Sr. Business Development Manager
781-972-5483
jstroup@healthtech.com 


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