CONFERENCE SERIES: Drug Discovery & Development

Recorded at: The Bioprocessing Summit

Digital Course: Pharmacology and Drug Discovery in the Allosteric World



Order DVD2012 DOT DVD Cover About this Product: 

The advancing technology of high-throughput screening is changing the type of molecules found. With protein function more physiologically relevant, the quality of the molecules that pharmacologists and medicinal chemists must deal with is changing. This course will familiarize researchers with the tools needed to exploit this potentially fruitful area of new drug discovery through discussion of allosteric molecules, detection of allosterism, and quantifying allosterism for chemical lead optimization. The course is designed to answer these questions:

What is protein allostery?
What makes allosteric molecules unique and how can this contribute to unique therapeutic properties?
How can we detect allosterism?
How to quantify allosterism for chemical lead optimization?



About this Product:
2 Presentations
141 Slides
Over 113 Minutes
Individual: $345
Site License: $1380

Conference At A Glance: 

Terrence KenakinTerry P. Kenakin, Ph.D., Professor, Department of Pharmacology, University of North Carolina School of Medicine 
Terry Kenakin is Research Professor in the Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina. Terry obtained his B.S. in chemistry and Ph.D. in Pharmacology at the University of Alberta, Canada. After 3 years at University College, London, UK, he joined Burroughs-Wellcome as a Senior Research Pharmacologist. Terry then went on to join Glaxo, which became Glaxo-Wellcome and subsequently GlaxoSmithKline, where his work involved the use of quantitative receptor pharmacology and theory to advance new drug discovery programs. He applies quantitative pharmacologic concepts to drug dose-response data to provide medicinal chemists with scales to optimize drug activity. He has written 9 books on Pharmacology and is co-Editor-in-Chief of the Journal of Receptors and Signal Transduction and also Current Opinion in Pharmacology. His current interests center on the therapeutic exploitation of the 7TM receptor functional selectivity and allosteric control of the 7TM receptor signaling.

Annette GilchristAnnette Gilchrist, Ph.D., Assistant Professor, Pharmaceutical Sciences, Midwestern University
Annette Gilchrist received her M.S. in Biochemistry from the University of Connecticut and Ph.D. in Immunology from the University of Connecticut Health Center. Following a postdoctoral fellowship with Dr. Heidi Hamm, Dr. Gilchrist went on to cofound Caden Biosciences and Cue BIOtech, companies committed to GPCR drug discovery efforts. Currently, Dr. Gilchrist is an Assistant Professor in the Department of Pharmaceutical Sciences at Midwestern University’s Chicago of Pharmacy, and an Adjunct Professor at Northwestern University in the Department of Molecular Pharmacology and Biological Chemistry. Her work is focused on functional selectivity and allosteric regulation of GPCRs. Dr. Gilchrist has twenty-five peer-reviewed publications and four issued patents including a just publishedmanuscript that was cited as a "must read" by the Faculty of 1000. In addition, she recently served as editor for a book by Wiley entitled GPCR Molecular Pharmacology and Drug Targeting: Shifting Paradigms and New Directions 

About Discovery On Target: 

Discovery on Target is known as the leading event showcasing novel "hot" targets for the pharmaceutical industry will be held November 2-4 in Boston, Massachusetts at the historic Park Plaza Hotel & Towers.

This is a must attend event to keep up with current and upcoming developments in target discovery and to collaborate and connect with experienced scientists and high level decision makers.

Networking opportunities will be available through interactive sessions including roundtable breakouts, workshops and panel discussions.

Create your own agenda by moving between the conference programs and choose the sessions that best fit your research and networking needs.

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2014 Discovery on Target Brochure  

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The exhibit hall was sold out in 2013, so please contact us early to reserve your place. To customize your sponsorship or exhibit package for 2014, contact:

Jon Stroup
Business Development Manager

2014 Discovery On Target CAG 



October 8 – 9

Targeting Epigenetic Readers and
Chromatin Remodelers

Targeting the Ubiquitin Proteasome System  

Big Data Analytics and Solutions  

GPCR-Based Drug Discovery  

RNAi for Functional Genomics Screening
– Part 1

Protein-Protein Interactions as Drug Targets  

Antibodies Against Membrane Protein Targets
– Part 1

October 9 – 10

Targeting Histone Methyltransferases and Demethylases  

Screening Drug Transporter Proteins  

Maximizing Efficiency in Discovery  

GPCR-Targeted Therapeutics  

Genome Editing for Functional Genomics
Screens – Part 2

Cancer Metabolism  

Antibodies Against Membrane Protein Targets
– Part 2


October 7

Next Generation Histone Deacetylase Inhibitors  


October 7

SC1: Designing Scalable Software Systems for Big Data Analytics  

SC2: Approaches for Biologically-Relevant Chemical Diversity  

SC3: Setting Up Effective RNAi Screens: From Design to Data to Validation  

SC4: Targeting Protein-Protein Interactions  

SC5: GPCR Structure-Based Drug Discovery  

SC6: Advances in Metagenomic Drug Discovery for New Anti-Infective Agents  

SC7: Targeting of GPCRs with Monoclonal Antibodies  

SC8: A Primer to Gene Editing: Tools and Applications  

SC9: Introduction to Targeted Covalent Inhibitors  

October 9

SC10: Setting Up Effective Functional Screens Using 3D Cell Cultures  

SC11: Integration of BDDCS and Extended Clearance Principles  

SC12: Introduction to Allosteric Modulators and Biased Ligands of GPCRs  

SC13: Introduction to Drug Metabolism